Prince Frederik of Luxembourg, the son of Prince Robert of Luxembourg and Princess Julie of Nassau, passed away at the age of 22 after a long battle with POLG Mitochondrial disease. His untimely death has left his family and the people of Luxembourg mourning the loss of a young royal who dedicated his short life to raising awareness about his rare genetic condition.
Despite being diagnosed with the disease at the age of 14, Prince Frederik remained determined to make a difference. He founded the POLG Foundation, an organization committed to research and finding treatments for POLG Mitochondrial disease.
Born into Luxembourg’s royal family, Prince Frederik was known for his vibrant personality, strong will, and compassionate nature. His father, Prince Robert, described him as someone who was full of positivity, joy, and determination.
Even in the face of his debilitating illness, Frederik maintained an inspiring outlook on life, refusing to let the disease define him. His courage and resilience were evident in the way he continued to support others facing similar struggles, using his voice to bring awareness to the challenges of living with POLG disease.
A Courageous Battle Against POLG Mitochondrial Disease
Prince was first diagnosed with POLG Mitochondrial disease at the age of 14 when his symptoms began to manifest more clearly. This rare genetic disorder affects the body’s ability to produce energy at the cellular level, leading to progressive organ dysfunction and failure.
Because the disease impacts multiple organ systems, it is often difficult to diagnose in its early stages. Symptoms of POLG disease include muscle weakness, epilepsy, and liver failure, making it a devastating condition with no known cure.
Despite the challenges of living with such a complex disease, Prince Frederik remained unwavering in his commitment to raising awareness and helping others. His determination led to the creation of the POLG Foundation, an organization dedicated to finding effective treatments for the condition.
The foundation aims to support research initiatives and provide resources for families affected by POLG disease. Frederik’s vision for the foundation was to create a network of support and advocacy, ensuring that no one facing the disease felt alone.
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In his final days, Frederik demonstrated remarkable strength and composure. His father, Prince Robert, shared an emotional tribute in which he recounted the last moments of his son’s life.
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Frederik took the time to personally say goodbye to each of his loved ones, leaving them with a heartfelt message and even sharing a family joke in his final moments. His ability to bring comfort and laughter to his family, even as he faced the end, is a testament to the extraordinary character he possessed.
The Enduring Legacy of Prince Frederik of Luxembourg
Prince Frederik’s impact extended far beyond his royal lineage. His work with the POLG Foundation has already made significant strides in raising awareness about the disease, and his legacy will continue to inspire efforts to find a cure.
His family, including his parents, Prince Robert and Princess Julie, as well as his siblings, Prince Alexander and Princess Charlotte, remain committed to carrying forward his mission.
Luxembourg, a small but influential European nation, has mourned the loss of one of its most promising young figures. As a country with a rich history and a strong sense of community, Luxembourg has rallied around the royal family during this difficult time. The outpouring of condolences and support reflects the deep respect and admiration that people had for Prince Frederik and his contributions to society.

Beyond his advocacy work, Frederik was known for his kindness, intelligence, and humor. His father described him as having an incredible emotional intelligence, a strong sense of justice, and an unwavering commitment to fairness and decency. These qualities made him a beloved figure among those who knew him, and his absence will be deeply felt.
In a short film produced by the POLG Foundation, Frederik shared his thoughts on living with a rare genetic disease. Reflecting on his childhood, he spoke about the dreams and aspirations he had as a young boy and how his diagnosis slowly altered his reality.
Despite the limitations imposed by the disease, he never lost hope. His story serves as a reminder of the strength of the human spirit and the importance of perseverance in the face of adversity.
Prince Frederik’s passing is a significant loss for Luxembourg and for the global community fighting against rare genetic diseases. His efforts have paved the way for further research and advocacy, ensuring that future generations may benefit from the work he started. Though his life was tragically short, his impact will be felt for years to come.
let’s enjoy few years on earth with peace and happiness….✍🏼🙏